Basic Infertility Evaluation




In a single cycle, the likelihood of conception (achieving pregnancy) for a healthy young couple is approximately 20 percent. Over twelve months, the combined likelihood of achieving pregnancy is about 85 percent. It is important to know that these numbers will begin to decrease beginning in a woman's early thirties, declining even further after age thirty-five.

Multiple factors can affect a couple's ability to conceive. Generally, the causes can be divided into male and female categories.


                   Male Factor (40 percent)

                   Female Factor (40 percent)

                   Male & Female Factors (10 percent)

                   Unexplained (10 percent)


Therefore, a thorough evaluation of the infertile couple begins with investigation for both male and female causes of infertility. A summary table is also listed below.


Table I. Infertility Work up


ABNORMALITY

TEST

Male Factor

Semen Analysis

Ovulation Disorder

Basal Body Temperature Chart
Progesterone Level
Urine Ovulation Predictor Kit
Ultrasound
Endometrial Biopsy

Cervical Factor

Post Coital Test

Pelvic Factor

Hysterosalpingogram (HSG)
Laparoscopy
Hysteroscopy
Saline Infusion Sonography (SIS)



Evaluation of the male

Following a thorough patient history, an important part of the evaluation includes the semen analysis. To obtain a good specimen, we advise the patient to avoid ejaculation for 2-5 days before the appointment. The sample is usually obtained in the lab, but can also be obtained at home if kept warm and brought to the lab within a half-hour of collection. The specimen is then examined for the following features:

Sperm Concentration - This is the total number of sperm per volume of semen, counted in millions/milliliter.

Motility (Movement) - This is the percentage of forward-swimming sperm in the sample.

Morphology (Shape) - Sperm can have a number of different shapes. This is the percentage of normally-shaped
   sperm in the specimen.

Infection - The presence of many white blood cells may indicate that infection is present, which is treated with a
  course of antibiotics.


When an abnormality is noted, the patient will typically obtain a repeat specimen. If it remains abnormal, a referral to an urologist is sometimes recommended for a physical examination and further work-up.


Evaluation of the female

This evaluation starts with a detailed patient history and physical examination. Major points in the history include past illnesses and surgeries, menstrual cycle characteristics, previous pregnancies, and contraception (birth control). For women with irregular or infrequent cycles, the first step is to determine if ovulation (monthly release of an egg) is taking place. This can be done in several ways, with the first two listed below used most commonly:

Ovulation Predictor Kit - Using a home urine testing kit, we can measure luteinizing hormone (LH), a hormone that causes   ovulation. If the test is positive, it means ovulation will occur within 24-40 h.

Progesterone Level - When a woman ovulates, the ovaries produce the hormone progesterone. One week after ovulation,   the patient has blood drawn to test for this hormone. If it is above a certain level, this would indicate that ovulation has   occurred.

Basal Body Temperature - After ovulation, there is a small increase in a woman's body temperature, which lasts through   the second half of her cycle. To measure basal body temperature, a woman takes her temperature by mouth every morning   before she gets out of bed and records it on a chart. This record is usually kept for 2-3 menstrual cycles to see if ovulation is   occurring regularly.

Ultrasound - Using a vaginal ultrasound probe, an ultrasound has the ability to see a follicle (cyst with an egg inside).   Susequent collapse of a mature follicle would confirm ovulation. Typically, ultrasound is used for monitoring and timing of   fertility treatment.

Endometrial Biopsy - The lining of the uterus (endometrium) changes at ovulation. Using a narrow plastic catheter (tube),   an office biopsy can be obtained during the second half of the cycle and sent to the lab for study. This test is no longer   routinely used in the basic infertility work-up.


If the above tests demonstrate that a woman is ovulating, further tests and procedures may be performed to look for other causes of female infertility. These include:

Hysterosalpingogram (HSG) - An X-ray test that shows the inside of the uterus and fallopian tubes, performed right after   the menstrual period is completed. A small amount of dye is placed in the uterus through a thin tube inserted through
  the cervix. An X-ray is then taken. The fluid will fill the inside of the uterus and show its shape. We can also tell whether the   fallopian tubes are open by looking for fill and spill of dye.

Laparoscopy - A laparoscope is a small telescope that is placed through a small incision made in the navel. A video camera   is attached to this telescope, allowing us to examine all the pelvic organs and to look for any abnormal findings,
  such as endometriosis or adhesions (scar tissue). If these problems are found, they are usually treated at the same time.
  Dye can also be injected through the cervix to determine if the fallopian tubes are open. This is an outpatient
  surgical procedure that requires general anesthesia.

Hysteroscopy - A hysteroscope is a small telescope that is attached to a video camera. It is placed through the cervix, and   the uterus is filled with fluid. This allows us to see the inside of the uterus. Abnormalities that are found at this time can be   corrected. This procedure can be performed in the office, or in the operating room in conjunction with a laparoscopy.

Saline Infusion Sonography (SIS) - This is a simple ultrasound procedure to determine whether or not the uterine
  cavity is normal, and can be performed in the office. It involves placement of a small catheter just inside of the cervical
  opening to the uterus. Approximately 5 cc of saline is injected into the uterine cavity and a pelvic ultrasound is then   performed.






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